Valerie Tutwiler

Valerie Tutwiler

Assistant Professor

Biomedical Engineering

Office Hours: By Appointment
Website: Biomechanics of Blood Lab


Postdoctoral Fellow, University of Pennsylvania Perelman School of Medicine, 2017-2020
Ph.D, Biomedical Engineering, Drexel University, 2017
M.S., Biomedical Engineering, Drexel University, 2013
B.S., Biomedical Engineering, Drexel University, 2013


K99/R00 Pathway to Independence Award, NIH NHLBI
Promising Young Investigator, Council on Arteriosclerosis, Thrombosis and Vascular Biology for the American Heart Association
Regeneron Prize for Creative Innovation Finalist, Regeneron Pharmaceuticals
Travel to a Mentor Award, Thrombosis and Hemostasis Societies of North America
James Herbert Outstanding Leadership Award, Drexel University
Outstanding Dissertation Award, Drexel University
Predoctoral Fellowship, American Heart Association
Trainee Research Award, American Society of Hematology

Professional Affiliations

Professional Societies
     American Society of Cell Biology
Public Policy Committee, 2020 – Present
Mentor Match Task Force, 2020
Professional Development Task Force, 2019
Committee for Graduate Students and Postdocs, Co-chair of Career Development Subcommittee, 2014-2020
International Fibrinogen Research Society
American Heart Association
International Society of Thrombosis and Hemostasis
Biomedical Engineering Society 
North American Society of Thrombosis and Hemostasis
American Society of Hematology
Drexel University Board of Governors
Elected Director, 2019 – Present

Research Interests

Our research is focused on the structure and mechanics of blood clots. We are interested in examining mechanisms of bleeding and thrombosis, fibrin mechanics, and developing diagnostics and therapeutics for blood related disorders.

Selected Publications

Selected Publications


V. Tutwiler, A.D. Peshkova, G. Le Mihn, S. Zaytsev, R.I. Litvinov, D.B. Cines, J.W. Weisel.  Blood clot contraction differently modulated internal and external fibrinolysis. Journal of Thrombosis and Hemostasis. 2019 17(2):361-370


V. Tutwiler, A.R. Mukhitov, A.D. Peshkova, G. Le Minh, R.R. Khismatullin, J. Vicksman, C. Nagaswami, R.I. Litvinov, J.W. Weisel Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes. Scientific Reports. 2018 8:17907


J. Dai, D.Madeeva, V. Hayes, H.S. Ahn, V. Tutwiler, G.M. Arepally, D.B. Cines, M. Poncz and L. Rauova. Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood 2018 132(7):727-734.


P. Ma, S. Gupta, S. Sampietro, D. DeHanlian, V. Tutwiler, A. Tang, T.J. Stalker, L.F. Brass. The role of RGS10 in modulating the hemostatic response to injury. Blood Advances. 2018 2:2145-215. Featured as visual abstract


A.D. Peshkova, D.V. Malyasysov, R.A. Bredikhin, G. Le Minh, I.A. Andrianova, V. Tutwiler, C. Nagaswami, J.W. Weisel, R.I. Litvinov. Reduced contraction of blood clots in venous thromboembolism is a potential thrombogenic and embologenic mechanism. TH Open. 2018 02(01)e104-e115.


V. Tutwiler, H. Wang, R.I. Litvinov, J.W. Weisel. V.B. Shenoy. Interplay of Platelet Contractility and Elasticity of Fibrin/Erythrocytes in Blood Clot Contraction.  Biophys J. 2017 112(4):714-723. Featured on cover.


AD Peshkova, LM Giang, V Tutwiler, I.A. Andrianova, J.W. Weisel, R.I. Litvinov. A new link between inflammation and blood clotting: activated monocytes enhance clot contraction. Scientific Reports. 2017 7:5149


V. Tutwiler, A.D. Peshkova, I.A. Andrianova, D.R. Khasanova, J.W. Weisel, R.I. Litvinov. Contraction of blood clots is impaired in acute ischemic stroke. Athero Thromb Vasc Biol. 2017 37:271-279. Featured on cover


V. Tutwiler, R.I. Litvinov, A.P Lozhkin, A.D. Peshkova, T. Lebedeva, F.I. Ataullakhanov, K.L. Spiller, D.B. Cines, J.W. Weisel. Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood. Blood. 2016 127(1):149-159.


V. Tutwiler, D. Madeeva, H. Ahn, I. Andrianova, V. Hayes, X.L. Zheng, C.B. Cines, S. McKenzie, M. Poncz, L. Rauova, L. Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood. 2016 127(4):464-472. Featured on cover.