My research integrates design of biomedical engineering (BME) systems with mechanistic biology and clinical application. The laboratory has developed microfluidic systems to correlate cell migration with altered signaling pathways across a wide range of bio-applications, including repair of the central, visual and peripheral nervous systems (NS). My current projects focus on neuronal and glial cell replacements and their implications for regenerative, cell-based therapies across the NS. I have additionally integrated my research with educational initiatives in health disparities (HD) to address the profound diversity of health challenges among USA adults. The laboratory has been awarded funding for research and educational initiatives from the NIH (General Medicine, Cancer, Eye), NSF (Chemical, Bioengineering and Transport Systems, National Nanotechnology Initiative) and DoD (Office of Scientific Research).
Technical Areas: Photoreceptor Transplantation, Muller and Schwann Glia, Electro-chemotaxis https://orcid.org/0000-0002-6184-3103
Lab Website: https://www.vazlab.org/
ENGINEERING EMPLOYMENT HISTORY
Mechanical Engineer-Cleanroom Support, Intel Corporation (Portland, OR): 1992-1994
Cleanroom Development and Micro-contamination, Intel Corporation (Santa Clara, CA): 1994-1996
Teaching Assistant, MIT Dept. of Mechanical Engineering (Cambridge, MA): 1997-1999
Research Assistant, MIT Whitehead Institute for Biomedical Research (Cambridge, MA): 1999-2001
Assistant Professor, Dept. of Mechanical Engineering, City College of New York (CCNY): 2001-2002
Assistant Professor and Co-founding Member, Dept. of Biomedical Engineering, CCNY: 2002-2005
Associate Professor, Dept. of Biochemistry, Graduate City University of New York (NY): 2006-2018
Associate Professor (tenured), Dept. of Biomedical Engineering, CCNY (NY): 2006-2018
Associate Professor (tenured), Dept. of Biomedical Engineering, Rutgers University (NJ): 2019- Present
2020 Inducted into the American Institute for Medical and Biological Engineering (AIMBE) Class of 2020. https://aimbe.org/2020-fellows/
2019 Keynote Speaker, Fairleigh Dickinson University (Madison, NJ) Inaugural Meeting of the FDU Women in Science Nov 6, 2019. Women at the Eye and STEM of Society https://www.fdu.edu/about/university-leadership-offices/university-provost/women-in-science/
2018 Keynote Speaker, University of Florida (Gainesville) 7th Annual Pruitt Research Day Nov 16, 2018. The Eye in Biomedical Engineering: The Unknown and the Unexpected https://www.bme.ufl.edu/node/2371
2017 Keynote speaker at BCC Hidden Figures: Women in STEM Luncheon, Bronx Community College http://photosbywarrenkthompson.zenfolio.com/bcchiddenfigureswomeninstem11022017
2017 Invited Speaker at Gordon Research Conference in Microfluidics, Lucca (Barga) Italy: Microfluidics for the Visual System https://www.grc.org/programs.aspx?id=13022
2017 Winner of President's Award for Excellence: Recognizes CCNY faculty members for their innovative approaches in mentoring, research, teaching, scholarship and serving as exemplary models for excellence in scholarship, teaching and student success. https://www.ccny.cuny.edu/bme/news-0
2015 Hispanic Outlook in Higher Education Magazine, CUNY Decade of Science (August 7, 2015) http://www.hispanicoutlook.com/mary-ann-cooper/2015/8/7/hunter-college-cuny-celebrates-achievements-by-women-of-all-colors-in-decade-of-science
2013 Univision Televised Reporting (Channel 41), 'STEM and the Elusive Latina Role Model,' (August 12, 2013; Starts at 18:15min) https://www.youtube.com/watch?v=UkHtpsgybXg
2013 New York City Council, Televised Panel Discussion led by State Senator Y. Rodriguez, 'CUNY Stem Initiatives,' September 17, 2013
2012 Hispanic Outlook in Higher Education Magazine, Latina Faculty Reshaping (February 27, 2012) http://anthropology.usf.edu/faculty/data/Feinberg2012-Latina_Faculty_Reshaping_Higher_Education_-_Iraida_Carrion1.pdf
2011 Keynote Speaker, New York City Science and Engineering Fair (NYCSeF) at the American Museum of Natural History (Opening for visit from US President Barack Obama http://nycsef.cuny.edu/2070/), 'Bitten by the Science Bug' (March 29, 2011) http://academicworks.cuny.edu/cc_pubs/355/.
2011 Keynote Speaker Podcast, CUNY Lecture Series: The Science of Female Negotiation (Dec 20, 2011) http://www1.cuny.edu/mu/podcasts/2011/12/20/the-science-of-female-negotiation/
SOCIETY MEMBERSHIPS: Biomedical Engineering Society (BMES); The American Association for the Advancement of Science (AAAS); The Association for Research in Vision and Ophthalmology (ARVO); American Institute for Medical and Biological Engineering (AIMBE); Society of Women Engineers (SWE); Society of Hispanic Professional Engineers (SHPE)
ACADEMIC LEADERSHIP: Biomedical Engineering Society Health Disparities Special Interest Group (BMES 2015-17); Coulter College for Translation of BME Innovation (2015-2017); ABET coordinator (CCNY 2010-2016); Master’s in Translational Medicine (MTM) Founding Committee for Biodesign (CCNY 2015-2018); Co-founding faculty member of the CCNY BME Department (2002-2005).
COMMUNITY OUTREACH: Invited panelist: Importance of Minority Serving Institutions (NSF 2014-2017); HBCU/MSI Career Panels (DoD 2009-2011), Minority Partnership Programs (NIH 2004-2008); Media: Hispanic Outlook in Higher Education Magazine: CUNY Decade of Science (2015); Univision STEM and the Elusive Role Model (2013, Channel 41); New York City Council (State Senator Y. Rodriguez) Televised Discussion of STEM initiatives (2013); CUNY Lecture Series: The Science of Female Negotiation (2011 Keynote Speaker Podcast). Student Societies: Society of Hispanic Professional Engineers (SHPE) Graduate Research Symposium Chair (2009-2012), Northeast Regional Conference session chair (2002-2005); Society of Women Engineers (SWE) CUNY faculty advisor (2001-2008).
MENTORING ACTIVITIES: President’s Award for Excellence in Research, Mentoring and Teaching (2017 CCNY); Biomedical Engineering Society Department Diversity Award (2015, BMES); Young Leadership Award (2012, 100 Hispanic NY Women Inc.); Mentoring Awards: NSF Louis Stokes Alliance for Minority Participation (2010, CCNY); Alfred P. Sloan Foundation for Minority Education (2007); NSF Bridge to the Doctorate Programs and Faculty Mentoring (2005); CUNY High School Summer STEM Institute Research Director (2014-2018).
CONFERENCE ENGAGEMENT: Biomedical Engineering Society (BMES) conference abstract reviewer (2006-2014), session co-chair (glial engineering 2013, microenvironments 2011-2012, cell motility 2009 and cancer metastasis 2005-2007) and track co-chair (micro- and nano-technologies 2015). BMES Special Interest Groups in Cell and Molecular Bioengineering (2012-2017), Health Disparities (2014-2017), National Society of Black Engineers (NSBE) industry initiatives (2017) and Coulter College for Translation of BME Innovation (2014-2017). American Institute of Chemical Engineering (AIChE) conference abstract reviewer (2001-2006) and co-chair of AIChE joint session with American Electrophoresis Society (2003-2002).
PROFESSIONAL SERVICE: Proposal reviewer for NSF (EECS, 2005-2009, MRI, 2005-2007, CBET 2003-2009, NER 2003-2006). Proposal reviewer for NIH (ISD study section ad-hoc 2007-2017, Special Emphasis Panel (NEI 2016, NIBIB 2013-2017, NIGMS 2010-2012, NCI 2008-2010), Shared Instrumentation Panel (NIBIB 2009, NIGMS 2006-2007). Reviewer of State Awards: Louisiana Innovation in Engineering Research Fund (2010-2012); University of Connecticut Internal Grants (2011-2009); Ohio Office for the Advancement of Research Scholarship (2008-2009). Reviewer of International Awards: Universidad Panamericana de Cuenca (Ecuador, 2013-2015); Universidad de Monterrey (Mexico, 2011-2012); University of British Columbia (Canada, 2008-2011). Journal reviewer for: Analytical Chemistry, Annals of Biomedical Engineering, Biosensors, Brain Research, Journal of Nanoscience and Nanotechnology, Journal of Pediatric Biochemistry, Nanomedicine, Nature Communications; MIT Corporation Visiting Committee Mechanical Engineering (2002-2010).
TECHNOLOGY PLATFORMS: Microfluidics-Based Biosystems; Nanotechnology and Intracellular Imaging
BIOLOGY EMPHASIS: Cell Motility and Collective Migration; Glial and Neuronal Progenitor Biology; Neuromuscular Junction (NMJ)
CLINICAL TRANSLATION: Photoreceptor Transplantation; Schwann Cell Delivery; Health Disparities
EDUCATION AND OUTREACH: Health Disparities Challenges for Engineers; Biodesign and Innovation for Engineers; Undergraduate Research Programs
Recent Peer-reviewed Manuscripts (ORCID: 0000-0002-6184-3103):
Pena, J.S.; Vazquez, M., VEGF upregulates EGFR expression to stimulate chemotactic behaviors in Müller glia, Brain Sci 2020, 10(6), 330. https://pubmed.ncbi.nlm.nih.gov/32485834
Zhang S., Markey M., Pena D.C., Venkatesh V., Vazquez, M., ‘A micro-optic stalk to evaluate the collective migration of retinal neuroblasts,’ Micromachines (Basel). 2020 Mar 31;11(4). https://www.ncbi.nlm.nih.gov/pubmed/32244321
Singh, T.; Robles, DR.; Vazquez, M., 'Neuronal substrates alter the migratory responses of non-myelinating Schwann cells to controlled BDNF gradients,' Journal of Tissue Eng Regen Med. 2020 Apr;14(4):609-621. https://www.ncbi.nlm.nih.gov/pubmed/32080982
McCutcheon S.; Majeska, R.; Spray, D.; Schaffler, M.B.; Vazquez, M., 'Apoptotic osteocytes induce RANKL production in bystanders via purinergic signaling and activation of pannexin channels,' J Bone Miner Res. 2020 May;35(5):966-977. https://www.ncbi.nlm.nih.gov/pubmed/31910292
Pena C.; Zhang, S.; Markey, M..; Venkatesh, T.; Vazquez, M., 'Collective behaviors of Drosophila-derived retinal progenitors in controlled microenvironments,' PLoSOne 2019 Dec 13;14, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226250
Pena C.; Zhang, S.; Majeska, R.; Venkatesh, T.; Vazquez, M., 'Invertebrate retinal progenitors as regenerative models in a microfluidic system,' Cells. 2019 Oct 22;8(10). https://www.mdpi.com/2073-4409/8/10/1301
Vazquez, M., 'Electro-chemotactic stimuli for cell replacement therapy in neurosensory retina,' Neural Regen Res. 2020 Mar;15(3):450-452. https://www.ncbi.nlm.nih.gov/pubmed/31571654
Peña JS.; Robles D.; Zhang S.; Vazquez M., 'A Milled Microdevice to Advance Glia-Mediated Therapies in the Adult Nervous System,' Micromachines (Basel). 2019 Jul 31;10(8). https://www.ncbi.nlm.nih.gov/pubmed/31370352
Mishra, S.; Pena, J.; Redenti, S.; Vazquez, M., 'A novel electro-chemotactic approach to impact the directional migration of transplantable retinal progenitor cells,' Exp Eye Res 2019, Aug;185:107688 https://www.ncbi.nlm.nih.gov/pubmed/31185219
Singh T.; Vazquez, M.; Time-Dependent Addition of Neuronal and Schwann Cells Increase Myotube Viability and Length in An In Vitro Tri-Culture Model of the Neuromuscular Junction,' Regen Eng and Transl Med 2019 https://doi.org/10.1007/s40883-019-00095-5
Pena J.; Vazquez, M., 'Reducing health disparities in adult vision loss via interfaces with emerging technology,' Nature Eye 2019, Apr;33(4):532-533. https://www.ncbi.nlm.nih.gov/pubmed/30518973
Pena J.; Dulger N.; Redenti, S.; Majeska R.; Vazquez, M., ‘Controlled microenvironments to evaluate chemotactic properties of cultured Muller glia,' Exp Eye Res 2018 May 19;173:129-137. https://www.ncbi.nlm.nih.gov/pubmed/29753729
Vazquez M., ‘Engaging Biomedical Engineering in Health Disparities Challenges,’J Community Med Health Educ 2018, 8: 595. https://www.ncbi.nlm.nih.gov/pubmed/31223515
Thakur A., Mishra S., Pena J., Zhou J., Redenti S., Majeska R., Vazquez, M., ‘Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials,’ J. Tissue Eng. (2018) Vol. 9: 1–14. https://www.ncbi.nlm.nih.gov/pubmed/29344334
Mishra S.; Vazquez, M., ‘A Gal-MµS device to evaluate cell migratory response to combined galvano-chemotactic fields,' Biosensors (Basel) 2017 Nov 21;7(4). https://www.ncbi.nlm.nih.gov/pubmed/29160793
Vazquez M.; Marte O.; Barba J.; Hubbard K.; 'An approach to integrating health disparities within undergraduate biomedical engineering education,' Ann Biomed. Eng. 2017 Nov;45(11):2703-2715. https://www.ncbi.nlm.nih.gov/pubmed/28849321
McCutcheon S.; Majeska R.; Schaffler M.B.; Vazquez M., 'A multiscale fluidic device for the study of dendrite-mediated cell to cell communication.' Biomed Microdevices, 2017 Aug 8;19(3): 71. http://www.ncbi.nlm.nih.gov/pubmed/28791515
Unachukwu, U.; Warren, A.; Zhou, J.;, Li, Z.; Mishra, S.; Sauane, M.; Lim, H.; Vazquez, M.*; Redenti, S.*; ‘Predicted molecular signaling guiding photoreceptor precursor cell migration following transplantation into damaged retina,’ Nature Scientific Reports 2016 Mar 3;6:22392 https://www.ncbi.nlm.nih.gov/pubmed/26935401
McCutcheon S.; Unachukwu U.; Thakur A.; Majeska R.; Redenti S.' Vazquez M., ‘In Vitro Formation of Neuroclusters in Microfluidic Devices and Cell Migration as a Function of Stromal-Derived Growth Factor 1 Gradients.’ Cell Adh Migr. 2016 Jan 8:0. https://www.ncbi.nlm.nih.gov/pubmed/26744909
Beck C.;, Singh T.; Farooqi A.; Venkatesh T.; Vazquez M., ‘Controlled microfluidics to examine growth-factor induced migration of neural progenitors in the Drosophila visual system,’ J Neurosci Methods. 2015 Dec 29;262:32-40. https://www.ncbi.nlm.nih.gov/pubmed/26738658
Mishra S.; Thakur A.; Redenti S.; Vazquez M., A model microfluidics-based system for the human and mouse retina,’ Biomed Microdevices. 2015 Dec;17(6):107 https://www.ncbi.nlm.nih.gov/pubmed/26475458
Rico-Valera J.; Singh T.; McCutcheon S.; Vazquez M.,’EGF as a therapeutic target for medulloblastoma metastasis,’ Cell Mol Bioeng 2015 July 1; Volume 3, Issue 2, pp323. Cell Mol Bioeng. 2015 Dec;8(4):553-565 https://www.ncbi.nlm.nih.gov/pubmed/26594253