Charles M. Roth


Office: BME-205
Office Hours: By appointment
Website: Charles M. Roth


Postdoctural, Bioengineering, Harvard Medical School, 1995-97
Ph.D., Chemical Engineering, University of Delaware, 1994
B.S.E., Chemical Engineering, University of Pennsylvania, 1989




Rutgers, FASIP Award for Teaching, Research and Service (ranked first in Department)


NSF Faculty CAREER Award

2002, 2006

Charles & Johanna Busch Biomedical Research Award


Whitaker Foundation Transitional Career Award


Whitaker Foundation Travel Award


Harvard Council on Biomedical Engineering Faculty Excellence Fellow


NIH Postdoctoral Fellowship


Robert L. Pigford Graduate Student Fellowship, University of Delaware


American Chemical Society Scholastic Achievement Award


Delaware Valley AIChE Junior Award


Benjamin Franklin Scholar, University of Pennsylvania

Professional Affiliations

  • Department of Chemical and Biochemical Engineering
  • Graduate Program in Biochemistry
  • Graduate Program in Cell and Developmental Biology
  • IGERT Training Program in Engineered Biointerfaces
  • IGERT Training Program in Nanopharaceutics
  • Center for Structured Organic Composites
  • New Jersey Center for Biomaterials

Research Interests

Our research involves the application of molecular and nanobioengineering approaches to cancer and to other biomedical problems. Much of our work centers on the development of technology for efficient gene silencing (using antisense or short interfering RNA). Current projects include: 1) novel lipid-polymer formulations for effective systemic and intracellular delivery of oligonucleotides; 2) silencing of osteogenic genes to prevent heterotopic ossification; 3) nanobioengineering of novel imaging agents toward image-guided tumor therapies; 4) understanding and targeting tumor stem cells; 5) surface and metabolic engineering of hepatocyte culture.

Selected Publications

Recent Papers:
1.   Waite CL, Roth CM. Binding and transport of PAMAM-RGD in a tumor spheroid model: The effect of RGD targeting ligand density. Biotechnol. Bioeng., 2011; Published online July 13; doi: 10.1002/bit.23255.
2.   Hamed SS, Roth CM. Mathematical modeling to distinguish cell cycle arrest from cell killing in chemotherapeutic concentration response curves. J. Pharmacokin. Pharmacodyn., 2011; 38:385-403.
3.   Yang H, Ierapetritou MG, Roth CM. Effects of amino acid transport limitations on cultured hepatocytes. Biophys. Chem., 2010; 152:89-98.