Prabhas V. Moghe

Vice Chancellor of Research & Innovation
Rutgers-New Brunswick
Distinguished Professor

Biomedical Engineering

Phone:848-445-6591
Fax:732-445-3753
Email:moghe@soe.rutgers.edu
Office:BME-315
Office Hours: By appointment
Website: Prabhas V. Moghe

Education

Post-Doctoral Fellow, Bioengineering, Harvard Medical School, 1993-1995
Ph.D., Chemical Engineering - Bioengineering, University of Minnesota,1993
B.S., Chemical Engineering, University of Bombay (UDCT), 1988

 

 

Honors

2015        Fellow of Biomedical Engineering Society (BMES)
2013        Distinguished Professorship, Rutgers University
2012        Fellow of Biomaterials Science and Engineering, International Societies of Biomaterials (Conferred at the World Biomaterials Congress, China, May 2012)
2012        First School of Engineering Faculty of the Year Award, Rutgers University
2008,9,11 Excellence in Teaching Award in Biomedical Engineering, Engineering Governing Council, Rutgers
2007        Invited Scholar: Institute for Teaching and Mentoring, Compact for Faculty Diversity, Washington DC.
2006        Leader in Diversity Award, Rutgers University
2004        Elected Fellow, American Institute of Medical and Biological Engineering
2003        Future Leaders in Biomedical Engineering, Whitaker Foundation Workshop
2000        Teaching Excellence Award - Dept. of Chemical & Biochemical Engineering, Rutgers
1999        American Heart Association Grant-in-Aid Award
1998        National Science Foundation CAREER Award
1996        Johnson & Johnson Discovery Award

Professional Affiliations

2018-          Vice Chancellor for Research and Innovation, Rutgers University – New Brunswick
2014-18       Research Director, Rutgers Engineering–Biomedical and Health Sciences Alliances and Partnerships
2013-          Distinguished Professor, Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, Rutgers Univeristy, NJ.
2012-4         Vice-Chair, Department of Biomedical Engineering, Rutgers University, Piscataway, NJ
2008-          Adjunct Professor of Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ.
2007-11       Director, Rutgers-UMDNJ Graduate Program in Biomedical Engineering
2007-          Professor, Department of Chemical and Biochemical Engineering, Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.
2008-          Director and Principal Investigator, NSF-Sponsored Rutgers Integrative Graduate Educational and Research Traineeship (IGERT) Program on Stem Cell Science and Engineering
2003-9         Director and Principal Investigator, NSF-Sponsored Rutgers Integrative Graduate Educational and Research Traineeship (IGERT) Program on Biologic Interfaces
2003-          Project Director, In Situ Profiling of Cell Dynamics on Polymeric Materials, NIH-Sponsored P41 Center at Rutgers, “Integrated Technologies for Polymeric Biomaterials”.
2001-3         Undergraduate Program Director, Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.
2001-          Associate Professor, Department of Chemical and Biochemical Engineering, Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.
1995-          Assistant Professor, Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ.

Research Interests

The Moghe lab investigates cell-biomaterial interactions and nanotechnologies for biomedical and health science applications.  A few research nuggets are summarized next.  The Moghe lab recently showcased the ability of short wave infrared emitting nanoprobes to discern multi organ cancer metastases (Nature Biomedical Engineering, 2017).  The Moghe team has advanced a new class of polymer nanotherapeutics for treatment of cardiovascular disease (PNAS, 2015).  Additional innovations from the Moghe lab include the design of innovative shortwave infrared imaging probes for deeper tissue imaging of micrometastatic lesions (Nature Communications 2013), a new concept of high content imaging informatics of stem cell phenotypes (PNAS, 2010; Scientific Reports, 2017), and an advance in the reprogramming and brain-transplantation of human induced neurons within 3D devices from induced pluripotent stem cells (Nature Communications 2016; selected by the NIH-NIBIB as one of its scientific highlights for 2016). 

Selected Publications

  1.  Kantamneni H, Zevon M, Donzanti MJ, Zhao X, Sheng Y Barkund SR, McCabe LH, Banach-Petrosky W, Higgins LM, Ganesan S, Riman RE, Roth CM, Tan MC, Pierce MC, Ganapathy V and Moghe PV, Surveillance nanotechnology for multiorgan cancer metastases.  Nature Biomedical Engineering 1, 993-1003 (2017) doi:10.1038/s41551-017-0167-9
  2. Kim JJ, Devita MS, Kulesa A, Bennett NK, Chahar S, Viswanath S, Lee EA, Jung G, Shao PP, Childers EP, Liu S, Garcia BA, Becker ML, Hwang NS, Madabhushi A, Verzi MP, and Moghe PV.  High Content Optical Nanoscopy of Stem Cell Phenotypes: Textural Fingerprinting of Epigenetic Marks.  Scientific Reports  7, 39406 (2017) doi:10.1038/srep39406.
  3. Vega SL, Liu E, Bennett NK, Arvind V, Bushman J, Sung HJ, Becker ML, Vidi PA, Lelievre S, Kohn J, and Moghe PV.  Nuclear Mitotic Apparatus Molecule (NuMA) Organization as a Single Cell Phenotypic Classifier.  Exp Cell Res 2017 Feb 1;351(1):11-23. doi: 10.1016/j.yexcr.2016.12.018
  4. Chmielowski RA, Abdelhamid DS, Faig JJ, Petersen LK, Gardner CR, Uhrich KE, Joseph LB, Moghe PV.  Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation.  Acta Biomater. 2017. pii: S1742-7061(17)30311-2. doi: 10.1016/j.actbio.2017.05.029.
  5. Bennett NK, Chmielowski R, Abdelhamid DS, Faig JJ, Francis N, Baum J, Pang ZP, Uhrich KE, Moghe PV.  Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity.  Biomaterials. 2016 Oct 4;111:179-189. doi: 10.1016/j.biomaterials.2016.10.001.
  6. Kwan WL, Bennett NK, Skepper JN, Martynyuk N, Wijeyekoon R, Moghe PV, Williams-Gray CH, and Baker R.  α-Synuclein pre-formed fibril impairs blood-brain barrier tight junction protein expression without affecting cerebral endothelial permeability.  Exp. Neurology 2016 Nov;285(Pt A):72-81.
  7. Kilian KA, Moghe PV. High throughput strategies for the design, discovery, and analysis of biomaterials.  Acta Biomater. 2016 Apr 1;34:v-vi. doi: 10.1016/j.actbio.2016.03.019.
  8. Francis NL, Bennett NK, Halikere A, Pang ZP, and Moghe PV.  Self-Assembling Peptide Nanofiber Scaffolds for 3-D Reprogramming and Transplantation of Human Pluripotent Stem Cell-Derived Neurons.  ACS Biomaterials Sci & Eng 2016, 2 (6), pp 1030–1038
  9. Carlson AL, Bennett NK, Francis N, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang Z, and Moghe PV.  Generation and Brain–Transplantation of 3-D Microscale Networks of Reprogrammed Human Neurons.  Nature Communications 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862.
  10. Bennett NK, Dhaliwal A, and Moghe PV.  High throughput and high content micoenvironment screens for stem cell regenerative biology.  Invited Review.  Current Pharmacology Reports.  June 2016, Volume 2, Issue 3, pp 142–151.
  11. Dhaliwal A, Brenner M, Wolujewicz P, Zhang Z, Mao Y, Batish M, Kohn J, Moghe PV.  Profiling stem cell states in three-dimensional biomaterial niches using high content image informatics.  Acta Biomater. 2016 Nov;45:98-109. doi: 10.1016/j.actbio.2016.08.052.
  12. Zhang Y., Li Q., Welsh W.J., Moghe P.V. and Uhrich K.E.  Micellar and Structural Stability of Nanoscale Amphiphilic Polymers: Implications for Anti-atherosclerotic Bioactivity.  Biomaterials.  2016 84:230-40.
  13. Chan J., Lewis D.R., Petersen L.K., Moghe, P.V., and Uhrich, K.E.  Amphiphilic Macromolecule Nanoassemblies Suppress Smooth Muscle Cell Proliferation and Platelet Adhesion.  Biomaterials. 84:219-29. doi: 10.1016/j.biomaterials.2015.12.033.
  14. Higgins LM, Zevon M, Ganapathy V, Sheng Y, Tan MC, Riman RE, Roth CM, Moghe PV, Pierce MC.  Line-scanning confocal microscopy for high-resolution imaging of upconverting rare-earth-based contrast agents. J. Biomed. Opt. 2015 20(11):110506.
  15. Lewis DR, Petersen LK, York AW, Chae HB, Zablocki KR, Joseph LB, Uhrich KE, Haser PB, Moghe PV. Nanotherapeutics for Inhibition of Atherogenesis and Modulation of Inflammation in Atherosclerotic Plaques.  Cardiovasc. Research  2015 Oct 14, pii: cvv237, PMID 26472131.
  16. Zevon M, Kantamneni H, Ganapathy V, Kim P, Riman RE, Roth CM, and Moghe PV.  CXCR-4 targeted short-wave infrared emitting nanoprobes for enhanced deep tissue imaging and micrometastatic lesion detection  Small 2015 doi: 10.1002/smll.201502202.
  17. Ganapathy V, Moghe PV, and Roth CM.  Targeting tumor metastases: Drug delivery mechanisms and technologies.  J. Controlled Release 2015 219:215-23.
  18. Lewis DR, Petersen LK, York AW, Zablocki KR, Joseph LB, Kholodovych V, Prud'homme RK, Uhrich KE, and Moghe PV.  Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo.  Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2693-8.
  19. Abdelhamid DS, Zhang Y, Lewis DR, Moghe PV, Welsh WJ, and Uhrich KE.  Tartaric acid-based amphiphilic macromolecules with ether linkages exhibit enhanced repression of oxidized low density lipoprotein uptake. Biomaterials. 2015 Jun;53:32-9. doi: 10.1016/j.biomaterials.2015.02.038.
  20. Martin AA, Tomasini M, Kholodovych V, Gu L, Sommerfeld SD, Uhrich KE, Murthy NS, Welsh WJ, Moghe PV.  Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes.  J Funct Biomater. 2015 Apr 8;6(2):171-91. doi: 10.3390/jfb6020171.
  21. Vega SL, Dhaliwal A, Arvind V, Patel PJ, Beijer NR, de Boer J, Murthy NS, Kohn J, Moghe PV.  Organizational metrics of interchromatin speckle factor domains: integrative classifier for stem cell adhesion & lineage signaling.  Integr Biol (Camb). 2015 Apr 7;7(4):435-46. doi: 10.1039/c4ib00281d.
  22. Shreiber DI, Moghe PV, and Roth CM.  Multidisciplinary “Boot Camp” Training in Cellular Bioengineering to Accelerate Research Immersion for REU Participants.  Advances in Engineering Education.  Summer Issue 2015, 1-15