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Charalampos (Babis) Kalodimos
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| Address: |
599 Taylor Road |
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Piscataway, NJ 08854 |
| Room: |
209 |
| Phone: |
732-445-4500 x6209 |
| Email: |
babis@rci.rutgers.edu |
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| The main research interests of the lab have been focused on the elucidation of the molecular and mechanistic basis of a wide range of important biological phenomena. Our current and future efforts are directed towards understanding how central biological processes, such as transcription regulation, protein translocation and secretion, cell signaling, and protein folding take place. A detailed characterization of biomolecular interactions necessarily involves investigation of the inter-relationship between function, structure, dynamics, kinetics and energetics of a system. Towards this challenging goal, we employ state-of-the-art NMR spectroscopy methodologies complemented by many other biochemical and biophysical techniques. NMR spectroscopy in particular is a very powerful methodology that allows the study of the three-dimensional structure of biomolecules in semi-physiological conditions. Furthermore, NMR spectroscopy can provide a unique insight into the dynamic aspects of the macromolecules and their interaction with ligands over time. |
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Recent Papers:
1. Gelis I, Bonvin A, Keramisanou D, Economou A. Kalodimos CG (2007) Structural basis for signal sequence recognition by the 204-kDa translocase motor SecA determined by NMR. Cell. 131:756-769.
2. Sarkar P, Reichman C, Saleh T, Birge RB, C.G. Kalodimos CG (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein. Molecular Cell. 25: 413-426.
3. Popovych N, Sun S, Ebright RH, Kalodimos CG (2006) Dynamically driven protein allosteric cooperativity. Nature Structural & Molecular Biology. 13: 831-838.
Lab web site
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Latest News |
Kalodimos Wins Young Investigator Award
November 23, 2009
Professor Charalampos (Babis) Kalodimos has been selected as the 2010 winner of the young investigator award of the Protein Society. The award is named after the late Irving Sigal and includes a...
Graduate Student Awarded 3-yr DoD Fellowship on Prostate Cancer
November 13, 2009
Pallavi Tiwari (LCIB member and 2nd year BME PhD student) has been awarded a 3 year, $100K, Department of Defense fellowship for her project entitled "Computerized Decision Support System for Detection...
Graduate Students Win Conference Travel Awards
November 11, 2009
BME PhD students Kiana Aran and Mercedes Morales from Dr. Jeffrey Zahn's laboratory have received conference travel awards from the Graduate School to help defray travel costs to the Microtas...
BME Graduate Student wins 2 year NJCCR fellowship
November 10, 2009
LCIB member and BME PhD graduate student, Ajay Basavanhally has been awarded a 2 year predoctoral fellowship from the New Jersey Commission on Cancer research for his project entitled “Quantitative...
More News >>
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